T-Detect COVID is authorized under the FDA Emergency Use Authorization (EUA).

Want to know if you had an immune response to the virus that causes COVID-19?

T cells have the answer.*

Want to know if you had an immune response to the virus that causes COVID-19?

T cells have the answer.*

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Order Patient

1. Order

Answer some eligibility questions and submit payment.
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Account Set Up

2. Test authorization

An independent healthcare provider will review your responses and, if appropriate, authorize your test.

Blood Draw

3. Blood draw

A certified phlebotomist will draw your blood.

Results

4. Results

Adaptive Biotechnologies will process the blood sample and share results with you via a secure email from PWNHealth.

Estimated time for test results is 7-10 days from the time of your blood draw.

Adaptive has partnered with PWNHealth, an independent healthcare provider network, to authorize tests, when appropriate.

Why T cells?

  • T cells are the first responders of the adaptive immune system.
  • T-cell responses can persist in the blood long after antibody responses wane.1, 2
  • High specificity: Each T cell recognizes a very specific piece of the virus. All of your T cells together (your T-cell response) can see many parts of the virus. Most antibody tests only look for one part of the virus (e.g., spike protein).3
  • In a study, T-cell responses were detected up to 15 months after initial COVID-19 infection with 86% sensitivity.4

Time since infection

T cells persist longer than antibodies

* Based on prior research on other coronavirus T-cell responses. 2, 5

Patients Specificity Data

Specificity of a test is its ability to designate an individual who does not have a disease as negative. A highly specific test means that there are few false positive results.

T cells vs. antibodies

In some studies, T-cell testing outperformed leading antibody tests.6,7

Sensitivity

T-Detect Sensitivity

"Sensitivity" based on positive percent agreement (PPA) with PCR testing.
Sensitivity refers to a test’s ability to designate an individual with disease as positive. A highly sensitive test means that there are few false negative results, and thus fewer cases of disease are missed.

References

  1. Tay MZ, et al. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020.
  2. Ng O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016.
  3. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection. Nat Immunol. 2021.
  4. Gittelman RM, et al. Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection. JCI Insight. 2022. doi:10.1172/jci.insight.151849.
  5. Channappanavar R, et al. Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. J Virol. 2014.
  6. Dalai S, et al. Clinical validation of a novel T-cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection. Clin Infect Dis. 2022. doi:10.1093/cid/ciac353.
  7. Elyanow R, et al. T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity. JCI Insight. 2022. doi:10.1172/jci.insight.150070.

*The performance of T-Detect COVID has not been established in individuals who have received a COVID-19 vaccine.

T-Detect COVID is not FDA cleared or approved. It is authorized for emergency use under an Emergency Use Authorization (EUA). T-Detect is not indicated for use in patients under age 18.