• T cells are the first responders of the adaptive immune system and activate the antibody response. While antibodies naturally wane and are detectable in the shorter term, T cell responses persist in the blood long after antibody responses wane.¹
• The T-Detect COVID Test can detect T cells in your blood sample that can remain for up to several months after symptoms appear.^1,2,3

1. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection. bioRxiv. 2020.
2. Channappanavar R, et al. Virus-specific memory CD8 T cells provide substantial protection from lethal Severe Acute Respiratory Syndrome Coronavirus infection. J Virol. 2014;88(19):11034-11044.
3. Ng O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016;34(17):2008-2014.

• T cells are key players in the adaptive immune system.When your body is invaded by a foreign substance like a virus or bacteria, the immune system begins to rally one of its earliest lines of defense, helper T cells, to join the fight.
• Helper T cells may call on their allies to kickstart antibody production to
  support the fight against the disease. Helper T cells also alert killer T cells to foreign invaders to be destroyed.
• After your body has fought off an infection or disease, a small number of T cells remain in the blood. They are called memory T cells and their job is to remember how to ward off these invaders if they ever return.
• By mapping the T cells that fought off a disease and detecting them in a blood sample, we can diagnose many diseases at once.

The T-Detect COVID Test can detect an immune response to SARS-CoV-2, the virus that causes COVID-19 disease, to assess recent or past infection. It is not intended for the diagnosis of active/current SARS-CoV-2 infection.

In preliminary studies, when the T-Detect COVID Test was compared with serology testing:

• In one study, ~2 months after PCR Diagnosis, the T-Detect COVID test detected 97% of COVID positive patients, while the serology (antibody) tests had a range of 77-97% detecting of COVID positive patients.¹
• In another study, 5+ months after PCR diagnosis, the T-Detect COVID test detected 95% of COVID positive patients, while the serology (antibody) tests had a range of 52-71% in detection of COVID positive patients.²
• In studies, T-Detect COVID Test showed a specificity of >99%.²

1. Gittelman RM, et al. Diagnosis and tracking of past SARS-CoV-2 infection in a large study of Vo’, Italy through T-cell receptor sequencing. medRxiv. 2020.
2. Adaptive Data on File

A T cell response is typically detectable in blood several days after initial infection. How long this response lasts post-infection and the implication for immunity are not known. In this study, T cells were shown to persist in the blood for more than six months after initial infection¹ and studies of other coronaviruses show T cells responses can persist for several years.^2,3

1. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection. oRxiv. 2020.
2. Channappanavar R, et al. Virus-specific memory CD8 T cells provide substantial protection from lethal Severe Acute Respiratory Syndrome Coronavirus infection. J Virol. 2014;88(19):11034-11044.
3. Ng O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016;34(17):2008-2014.

• The T-Detect COVID Test can help you understand if you’ve had a recent or past COVID infection.
• The T-Detect COVID Test can provide answers if:
  • You still have symptoms and wondering if it is COVID?
  • You never got tested, but are concerned that you might have had COVID?
  • Got tested, but not sure you trust your test results
  • You are interested in supporting COVID research

The ordering process starts on the website. Below are the steps:

1. Order: Go to T-Detect.com to answer some eligibility questions and submit payment.
2. Prescription: Work with your doctor to complete the ordering process using our secure portal.
3. Blood Draw: We’ll order blood draw services and will send you a collection kit if mobile phlebotomy was selected.
4. Results: We’ll process the sample and share the results with your doctor via our secure portal.

Samples are processed within 5-7 days of receipt in the lab. Estimated total time for results is 7-10 days from the time of your blood draw.

The T-Detect COVID Test results are a positive or negative result. A positive result means there was a recent or past exposure to SARS-CoV-2, the virus that causes COVID-19, while a negative result indicates that past exposure to SARS-CoV-2 probably did not occur.

Mobile phlebotomy is a mobile blood draw service in which a certified phlebotomist (someone trained to draw your blood) visits your home to collect a blood sample.

ExamOne is a national mobile phlebotomy service provider that Adaptive Biotechnologies has partnered with to help provide blood draw services to patients.

The T-Detect COVID Test is available to be prescribed by healthcare professionals in all U.S. states, except for state of New York at this time. The state of New York requires laboratories conducting clinical testing on specimens from New York to obtain a special clinical laboratory permit. We are actively working with the proper regulatory bodies to gain the necessary approvals and we expect to provide access to the test in New York in early 2021. For updates on when the test is available to be prescribed in the state of New York,  please sign-up for email updates here.

The T-Detect COVID Test is only available in the United States and is not available in U.S. Territories.

The T-Detect COVID Test is available at a special price of $150* as part of our commitment to support testing options during the public health emergency and to improve our understanding of the role of T cells in COVID-19.

*The price does not represent the usual and customary charge for the T-Detect COVID Test, requires pre-payment, and is subject to change. The T-Detect COVID Test is currently not covered by health insurance.

If you’ve paid for the T-Detect COVID test and your doctor declines to prescribe it, contact our clinical services team at 855-236-9230 opt 1 and we will provide a full refund.

• The T-Detect COVID Test is not currently covered by insurance. The T-Detect COVID Test is FSA/HSA eligible. Patient is responsible for blood draw fees, co-pay for doctor visit, and any additional associated costs.
• You may qualify for discounted testing based on your income or medical expenses. Contact us at 855-236-9230 opt 3 to see if you might qualify for a reduced cost prior to placing your order. Please let the Agent know you are calling to see if you qualify for a reduced cost for a T-Detect COVID test.
• You may also print an Application Form for Financial Assistance for a reduced cost test and submit it to us using one of the methods below. If you qualify for a reduced cost, a refund will be processed to your credit card.
• You may return you application to AdaptiveBiotech@mylabbill.com or fax to 1 (440) 788-2137.

• Yes, you may qualify for discounted testing based on your income or medical expenses. Contact us at 855-236-9230 opt 3 to see if you might qualify for a reduced cost prior to placing your order. Please let the Agent know you are calling to see if you qualify for a reduced cost for a T-Detect COVID test.
• You may also print an Application Form for Financial Assistance for a reduced-cost test and submit it to us using one of the methods below. If you qualify for a reduced cost test, a refund will be processed to your credit card.

• Refunds and cancellations will be in accordance with the refunds and cancellation policy.
• Please contact the Clinical Services team at 888-552-8988 opt 1 within 24 hours if you wish to change or cancel your order. No refunds or cancellations can be made after 24 hours.
• If we are unable to provide a laboratory report after you submit your specimen: A refund will automatically be issued to the credit card you used and will be net of any costs for telehealth, phlebotomy, or other processing fees will be deducted. Contact the clinical services team at 888-552-8988 opt 1 with questions or concerns.
• If no valid test order was placed by the doctor: If you pay for the test, but your doctor decides you should not have the test and doesn’t prescribe, we will provide a full refund.