Doing COVID-19 research?

Study the T cell immune

response in COVID-19.

Contact Us

Doing COVID-19 research?

Study the T cell immune

response in COVID-19.

Contact Us

T cell responses arise earlier than antibodies and last through clearance into convalescence.1

The T-Detect COVID test is the first clinical test that detects T cells to confirm recent or past SARS-CoV-2 infections. T-Detect COVID test results are a binary positive/negative result. A positive result means there was a recent or past exposure to SARS-CoV-2, the virus that causes COVID-19. A negative result indicates that past exposure to SARS-CoV-2 probably did not occur.

Much of what we are learning about T cells is consistent with what we see in the immune response to other viruses, but the combination of global scientific focus and the number of people infected with the virus in such a short period of time has led to an understanding of the variability of individual responses on a greater scale. In the setting of COVID-19, we are seeing:

T cell responses arise earlier than antibodies and last through clearance into convalescence.1

T cells play a critical role in supporting the development of antibodies by B cells and can serve as the first signs of an immune response to SARS-CoV-2 infection.2

The majority of individuals with COVID-19 generate a T cell response comprised of both CD8+ T cells, or “killer” T cells which destroy virus-infected cells, and CD4+ “helper” T cells, which help other immune cells, including B cells which produce antibodies.3

CD8+ & CD4+ T cells were observed in convalescent patients with mild and severe COVID-19 disease.4

Frequently asked questions

How does the T-Detect COVID test work?

T cells are the first responders of the adaptive immune system and activate the antibody response. While antibodies to SARS-CoV-2 (the virus that causes COVID-19 infection) naturally wane and are detectable in the shorter term, T cell responses can persist in the blood long after antibody responses wane.1,2,4

The T-Detect COVID test can detect T cells in a blood sample that can remain for up to several months after symptoms appear.1,2,3

  1. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at six months following primary infection. bioRxiv. 2020.
  2. Adaptive data on file.
  3. Ng, O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016.
  4. Dalai, D, et al. Clinical Validation of a Novel T-Cell Receptor Sequencing Assay for Identification of Recent or Prior SARS-CoV-2 Infection. medRxiv. 2020.

In vitro diagnostic for prescription use only. This test has not been cleared or approved by the FDA. The T-Detect COVID Assay is available for use as a CLIA-validated laboratory developed test (LDT). T-Detect COVID is not indicated for use in patients under age 18.

immunoSEQ Technology is Research Use Only. Not for use in diagnostic procedures.

For Patients

The T-Detect COVID test can detect past COVID-19 infections for up to several months.

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For Physicians

The T-Detect COVID test can capture past COVID-19 infections that may be missed by serology testing.

For Employers

The T-Detect COVID test can help your employees get the answers they need.

References

  1. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection. bioRxiv. 2020.
  2. Channappanavar R, et al. Virus-specific memory CD8 T cells provide substantial protection from lethal Severe Acute Respiratory Syndrome Coronavirus infection. J Virol. 2014;88(19):11034-11044.
  3. Ng O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016;34(17):2008-2014.
  4. Gittelman RM, et al. Diagnosis and tracking of past SARS-CoV-2 infection in a large study of Vo’, Italy through T-cell receptor sequencing. medRxiv. 2020.