Doing COVID-19 research?

Study the T cell immune

response in COVID-19.

Contact Us to Order

Doing COVID-19 research?

Study the T cell immune

response in COVID-19.

Contact Us to Order

T cell responses arise earlier than antibodies and last through clearance into convalescence.1

The T-Detect COVID Test is the first clinical test that detects T cells to confirm recent or past SARS-CoV-2 infections. The T-Detect COVID Test provides a clear positive or negative answer, where a positive result confirms a past immune response to COVID-19 and a negative result confirms no past immune response to COVID-19.

Much of what we are learning about T cells is consistent with what we see in the immune response to other viruses, but the combination of global scientific focus and the number of people infected with the virus in such a short period of time has led to an understanding of the variability of individual responses on a greater scale. In the setting of COVID-19, we are seeing:

T cell responses arise earlier than antibodies and last through clearance into convalescence. 1

T cells play a critical role in supporting the development of antibodies by B cells and can serve as the first signs of an immune response to SARS-CoV-2 infection. 2

The majority of COVID-19 patients generate a T cell response comprised of both CD8+ T cells, or “killer” T cells which destroy virus-infected cells, and CD4+ “helper” T cells, which help other immune cells, including B cells which produce antibodies. 3

CD8+ & CD4+ T cells were observed in convalescent patients with mild and severe COVID-19 disease. 4

Why study T cells when measuring and monitoring an immune response to vaccines?

As we learn more about the role T cells play in immunity, vaccine developers are recognizing the need to measure the T cell response in addition to the antibody response to their vaccines. The same qualities that make a T cell test ideal for diagnostic purposes also underscore its utility for measuring immune response to vaccines. Adaptive recently launched a T cell monitoring research tool to offer vaccine developers a way to integrate our map of SARS-CoV-2-specific T cells into their vaccine trials.

This is the first molecular T cell monitoring tool for SARS-CoV-2 that accurately, quantitatively, and reproducibly measures the T cell immune response to vaccines and tracks the persistence of that response over time. We are providing data that map those TCRs to SARS-CoV-2 antigens, a capability that may significantly improve the ability to measure the immune response to vaccines in development. Importantly, we can do this from a simple blood sample that does not require any special storage or handling.

T Detect T Cell

Frequently Asked Questions

In vitro diagnostic for prescription use only. This test has not been cleared or approved by the FDA. The T-Detect COVID Assay is available for use as a CLIA-validated laboratory developed test (LDT). T-Detect COVID is not indicated for use in patients under age 18.

immunoSEQ technology is research use only. Not for use in diagnostic procedures.

For Patients

The T-Detect COVID Test can detect past infection months after exposure.

Learn More

For Physicians

The T-Detect COVID Test may capture COVID-19 infections missed by serology tests.

For Employers

The T-Detect COVID Test can help your employees get the answers they need.

References

  1. Zuo J, et al. Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection. bioRxiv. 2020.
  2. Channappanavar R, et al. Virus-specific memory CD8 T cells provide substantial protection from lethal Severe Acute Respiratory Syndrome Coronavirus infection. J Virol. 2014;88(19):11034-11044.
  3. Ng O, et al. Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection. Vaccine. 2016;34(17):2008-2014.
  4. Gittelman RM, et al. Diagnosis and tracking of past SARS-CoV-2 infection in a large study of Vo’, Italy through T-cell receptor sequencing. medRxiv. 2020.